What Is Keratin and What Is Its Purpose?

What Is Keratin and What Is Its Purpose?

Keratin is a fibrous structural protein found in animal cells and used to form specialized tissues. Specifically, the proteins are only produced by chordates (vertebrates, Amphioxus, and urochordates), which includes mammals, birds, fish, reptiles, and amphibians. The tough protein protects epithelial cells and strengthens certain organs. The only other biological material possessing similar toughness is the protein chitin, found in invertebrates (e.g., crabs, cockroaches). There are different forms of keratin, such as α-keratins and harder β-keratins. Keratins are considered examples of scleroproteins or albuminoids. The protein is rich in sulfur and insoluble in water. The high sulfur content is attributed to the richness of the amino acid cysteine. Disulfide bridges add strength to the protein and contribute to insolubility. Keratin is not typically digested in the gastrointestinal tract.

Keratin Word Origin

The word "keratin" comes from the Greek word "keras" which means "horn".

Examples of Keratin

Bundles of keratin monomers form what are called intermediate filaments. Keratin filaments may be found in the cornified layer of the skin's epidermis in cells called keratinocytes. The α-keratins include:

  • hair
  • wool
  • nails
  • hooves
  • claws
  • horns

Examples of β-keratins include:

  • scales of reptiles
  • reptile nails
  • bird claws
  • tortoise shell
  • feathers
  • porcupine quills
  • bird beaks

The baleen plates of whales also consist of keratin.

Silk and Keratin

Some scientists classify the silk fibroins that are produced by spiders and insects as keratins, although there are differences between the phylogeny of the materials, even if their molecular structure is comparable.

Keratin and Disease

While animal digestive systems aren't equipped to deal with keratin, certain infectious fungi feed on the protein. Examples include the ringworm and athlete's foot fungus.

Mutations in keratin gene can produce diseases, including epidermolytic hyperkeratosis and keratosis pharyngis.

Because keratin is not dissolved by digestive acids, ingesting it causes problems in people who eat hair (tricophagia) and results in vomiting of hairballs in cats, once enough hair has accumulated from grooming. Unlike felines, humans don't vomit hairballs, so a large accumulation of hair in the human digestive tract can cause the rare but fatal intestinal blockage called Rapunzel syndrome.